The microbiota is fundamental for health. But how these non-invasive microbes communicate with the rest of the body to influence host physiology is not fully understood. Researchers from Stockholm, Umeå, and Gothenburg Universities, Sweden report how the gut microbiota is essential for natural resistance to viral infections. They show that the release of the membrane vesicles from the gut microbiota leads to the systemic delivery of bacterial DNA to host cells. This triggers the cytosolic cGAS-STING-IFN-I axis for innate immune DNA sensing, thereby protecting distal organs against viral infections. The study is published in the journal Immunity.
The gut microbiota protects against viral infections by keeping the immune system alert – Read the full article